منابع مشابه
predictions of protein-protein interfaces within membrane protein complexes
background: prediction of interaction sites within the membrane protein complexes using the sequence data is of a great importance, because it would find applications in modification of molecules transport through membrane, signaling pathways and drug targets of many diseases. nevertheless, it has gained little attention from the protein structural bioinformatics community. methods: in this stu...
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In their target article, Triesch et al. (2006) propose a simple model to account for the emergence of gaze following behaviour in infants. They justify the simplifications of the model by asserting that they are interested in the conditions that are sufficient for the development of gaze following behaviour. I think, however, that some of these simplifications are not just sufficient but are al...
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Protein structure prediction and protein-protein docking are two fundamental problems in molecular biology. Solving these two problems require an effective potential function to select the correct models from an ensemble of alternative conformations. Such potentials should be able to accurately assess the relative changes in protein stability upon folding and upon complexation. Because residues...
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MOTIVATION A sizeable fraction of eukaryotic proteins contain intrinsically disordered regions (IDRs), which act in unfolded states or by undergoing transitions between structured and unstructured conformations. Over time, sequence-based classifiers of IDRs have become fairly accurate and currently a major challenge is linking IDRs to their biological roles from the molecular to the systems lev...
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Protein-DNA interactions play a central role in transcriptional regulation and other biological processes. Investigating the mechanism of binding affinity and specificity in protein-DNA complexes is thus an important goal. Here we develop a simple physical energy function, which uses electrostatics, solvation, hydrogen bonds and atom-packing terms to model direct readout and sequence-specific D...
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ژورنال
عنوان ژورنال: AAPS PharmSci
سال: 2002
ISSN: 1522-1059
DOI: 10.1208/ps040104